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Gupta, Mahesh P.
One or more keywords matched the following items that are connected to Gupta, Mahesh P.
Item TypeName
Concept Sirtuin 3
Concept Sirtuin 2
Concept Sirtuin 1
Academic Article Poly(ADP-ribose) polymerase-1-dependent cardiac myocyte cell death during heart failure is mediated by NAD+ depletion and reduced Sir2alpha deacetylase activity.
Academic Article Poly(ADP-ribose) polymerase-1-deficient mice are protected from angiotensin II-induced cardiac hypertrophy.
Academic Article SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70.
Academic Article SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1.
Academic Article The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.
Academic Article Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice.
Academic Article Mitochondrial SIRT3 and heart disease.
Academic Article The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun.
Academic Article Activation of SIRT1, a class III histone deacetylase, contributes to fructose feeding-mediated induction of the alpha-myosin heavy chain expression.
Academic Article Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway.
Academic Article Emerging roles of SIRT1 deacetylase in regulating cardiomyocyte survival and hypertrophy.
Academic Article SIRT3 deacetylates and activates OPA1 to regulate mitochondrial dynamics during stress.
Academic Article Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3.
Academic Article Obesity-induced lysine acetylation increases cardiac fatty acid oxidation and impairs insulin signalling.
Academic Article SIRT3 Blocks Aging-Associated Tissue Fibrosis in Mice by Deacetylating and Activating Glycogen Synthase Kinase 3ß.
Academic Article Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice.
Academic Article Role of Sirtuins in Regulating Pathophysiology of the Heart.
Academic Article SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis.
Academic Article SIRT3 blocks myofibroblast differentiation and pulmonary fibrosis by preventing mitochondrial DNA damage.
Academic Article Honokiol, an activator of Sirtuin-3 (SIRT3) preserves mitochondria and protects the heart from doxorubicin-induced cardiomyopathy in mice.
Academic Article SIRT2 regulates oxidative stress-induced cell death through deacetylation of c-Jun NH2-terminal kinase.
Academic Article SIRT2 deacetylase regulates the activity of GSK3 isoforms independent of inhibitory phosphorylation.
Grant Activation of sirtuins to prevent adverse cardiac remodeling after CABG
Grant Improving post-surgery recovery of failing hearts by targeting cardiomyocyte senescence
Grant Blocking cardiac toxicity of anticancer drugs
Academic Article The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity-mediated diabetic cardiomyopathy.
Academic Article Is nuclear sirtuin SIRT6 a master regulator of immune function?
Academic Article The nuclear sirtuin SIRT6 protects the heart from developing aging-associated myocyte senescence and cardiac hypertrophy.
Academic Article Skeletal muscle-specific over-expression of the nuclear sirtuin SIRT6 blocks cancer-associated cachexia by regulating multiple targets.
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  • Sirtuin 3